Interest in 3D printing living tissues has grown in recent years developing an effective way to use the technology has been difficult, particularly since accurately controlling the position of cells in 3D is hard to do.
As a result, it remains a challenge to print high-resolution living tissues.
Producing printed tissues in this way improves the survival rate of the individual cells, and allowed the team to improve on current techniques by building each tissue one drop at a time to a more favourable resolution.
The method enables the fabrication of patterned cellular constructs, which, once fully grown, mimic or potentially enhance natural tissues.
Dr Alexander Graham, lead author and 3D Bioprinting Scientist at OxSyBio, said: “We were aiming to fabricate three-dimensional living tissues that could display the basic behaviours and physiology found in natural organisms. To date, there are limited examples of printed tissues, which have the complex cellular architecture of native tissues. Hence, we focused on designing a high-resolution cell printing platform, from relatively inexpensive components, that could be used to reproducibly produce artificial tissues with appropriate complexity from a range of cells including stem cells”.
Over the coming months they will work to develop new complementary printing techniques, that allow the use of a wider range of living and hybrid materials, to produce tissues at industrial scale.
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