Researchers from the Max Planck Institute of Biochemistry and the German Heart Centre at the Technical University of Munich have now determined which and how many individual proteins are present in each type of cell in the heart.
They have now compiled the first atlas of the healthy human heart, known as the cardiac proteome.
For such changes to be recognized as underlying causes of heart disease, it is important to know precisely which proteins are present in the healthy heart and in what quantities.
The first such protein atlas of the heart was recently published in Nature Communications by a research team from Munich.
“First, the results did not give a full picture of the heart across all its regions and tissues; and second, comparative data on healthy hearts were often missing. Our study has eliminated both problems. Now, the data can be used as a reference for future studies.”
“Looking at the protein atlas of the human heart, you can see that all healthy hearts work in a very similar manner. We measured similar protein compositions in all the regions with few differences between them,” she says.
More information: Sophia Doll et al, Region and cell-type resolved quantitative proteomic map of the human heart, Nature Communications.