Scientists find key proteins control risk of osteoarthritis during aging

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Now, a study from scientists at The Scripps Research Institute (TSRI) explains why the risk of increases as we and offers a potential avenue for developing new therapies to maintain healthy .

The study’s findings suggest that proteins are responsible for the maintenance of  in the of our joints.

“We discovered that FoxO transcription factors control the  of  that are essential for maintaining joint ,” says Martin Lotz, MD, a TSRI professor and senior author of the study, published today in the journal Science Translational Medicine. “Drugs that boost the expression and activity of FoxO could be a strategy for preventing and treating .”

Previous research from Lotz’ lab showed that as joints age, levels of FoxO proteins in cartilage decrease. Lotz and his colleagues had also found that people with osteoarthritis have a lower expression of the needed for a process called . Autophagy (“auto” meaning “self” and “phagy” meaning “to eat”) is a cell’s way of removing and recycling its own damaged structures to stay healthy.

For the new study, researchers used mouse models with FoxO deficiency in cartilage to see how the FoxO proteins affect maintenance of cartilage throughout adulthood.

Full Study  Here.

Post Author: Nicholi Avery

Research, neuroscience, cognitive science, theoretical physics, biology, philosophy, and psychology.

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