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Spectral Signatures of Reorganised Brain Networks in Disorders of Consciousness

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Here, we apply graph theory to compare key signatures of such networks in high-density electroencephalographic data from 32 patients with chronic disorders of consciousness, against normative data from healthy controls.

These signatures, encompassing measures of topology as well as topography, will allow us to address a set of inter-related questions of fundamental neuroscientific importance: for example, what is distinctive about network dysfunction in pathological states of low awareness? To what extent are these network signatures consistent across patients? How do they correlate with the complexity of preserved behavioural responses? And perhaps most intriguingly, what network signatures can we observe in patients who seem behaviourally vegetative, but nevertheless demonstrate signs of covert awareness.

Previous research into resting state networks involving patients in acute coma and chronic disorders of consciousness has reported on the disruption of structural and functional connectivity following brain injury ,.

In contrast to previous findings indicating that brain networks in patients are variably disrupted , we found higher values of within-group NMI in their delta and theta band networks.

Our findings with regard to alpha band networks are also consistent with another recent analysis of EEG networks in a large cohort of patients , which found a reduction in long-range information sharing in DoC. However, it should be noted that while we attempted to ensure that the group differences and correlations observed in the graph-theoretic measures cannot be explained away by systematic sleep onset in patients, considerations of ongoing and rapid fluctuations of arousal and vigilance in patients during the recording warrant careful interpretation of the limitations and generalisability of these measures, both within and across groups.

Alongside the identification of damaged networks, our data highlighted the remarkable robustness of alpha connectivity in some behaviourally vegetative patients who also evinced high-level cognitive function by performing tennis imagery detected by fMRI. Hence, in such patients at least, we have found links between covert task-relevant attention and awareness, and the presence of brain networks that could support such advanced cognitive function despite the apparent lack of any consistent behavioural signs thereof.

In this context, our topographical evaluation of graph-theoretical network analysis identified a key distinction between brain networks in patients and controls: while alpha networks in controls were both topologically structured and topographically expansive, the topologically more robust delta/theta band networks in patients were not topographically expansive.

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Article originally posted at dx.plos.org

Post Author: Carla Parsons

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