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First detailed picture of a cancer-related cell enzyme in action on a chromosome unit

A landmark study to be published in the October 30, 2014 print edition of the journal Nature provides new insight into the function of an enzyme related to the BRCA1 breast-cancer protein. The study by a team at Penn State University is the first to produce a detailed working image of an enzyme in the Polycomb Repressive Complex 1 (PRC1)-a group that regulates cell development and is associated with many types of cancer.