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Regeneration in distantly related species: common strategies and pathways

All animals capable of regenerating a lost body part, from an organ or a limb to the whole organism, use a common set of genes. This is the striking discovery of a team of researchers from the Center for Complexity and Biosystems of the University of Milan, led by Caterina La Porta. They analyzed the genetic activity in regenerating tissues from widely different species—from hydra to mice. They found that some of the genes active at the beginning of the regeneration process are the same in very different species, including mammals which have lost this function during evolution, except for the restoration of the liver. The discovery of this shared genetic signature is of great importance to understand how regeneration evolved and could be useful for future regeneration therapies.

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Doctors are gene editing inside the body of a living human for the first time

Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up…

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Gold nanoparticle used to replace virus in new CRISPR approach

(Phys.org)-A team of researchers from the University of California and the University of Tokyo has found a way to use the CRISPR gene editing technique that does not rely on a virus for delivery. In their paper published in the journal Nature Biomedical Engineering, the group describes the new technique, how well it works and improvements that need to be made to make it a viable gene editing tool.

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Nanotechnology Now – Press Release: ‘CRISPR-Gold’ fixes Duchenne muscular dystrophy mutation in mice

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease. A new study shows that a single injection of CRISPR-Gold, as the new delivery system is called, into mice with Duchenne muscular dystrophy led to an 18-times-higher correction rate and a two-fold increase in a strength and agility test compared to control groups.

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In Newly Created Life-Form, a Major Mystery | Quanta Magazine

Scientists have created a synthetic organism that possesses only the genes it needs to survive. But they have no idea what roughly a third of those genes do.

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Assay of nearly 5,000 mutations reveals roots of genetic splicing errors

Brown biologists have developed a new system, described in Nature Genetics, that identified and tracked hundreds of genetic variations that alter the way DNA is spliced when cells make proteins, often leading to disease.

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Team at Christiana Care develops new gene editing system that could help fight cancer

Dr. Eric Kmiec, Ph.D., is the director of the Gene Editing Institute of the Helen F. Graham Cancer Center & Research Institute at Christiana Care Health System. He and his