Targeting levels of specific protein could improve memory in aging, reduce symptoms of PTSD

A neural circuit mechanism involved in preserving the specificity of memories has been identified by investigators from the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HSCI). They also identified a genetic “switch” that can slow down #memory generalization — the loss of specific details over time that occurs […]

Mining the Microbial Dark Matter

The first time Robert Heinzen tried to get Coxiella burnetii to grow by itself, he failed miserably. The bacterium, which causes an influenza-like illness called Q fever, normally divides only inside the cells it infects — forcing researchers to grow it in mammalian tissue and hampering their efforts to investigate the microbe. When Heinzen tried to find […]

Our Individuality is Not Determined by Our Genes

Put 50 newborn worms in 50 separate containers, and they’ll all start looking for food at roughly the same time. Like members of other species, microscopic C. elegans roundworms tend to act like other individuals their own age. It turns out that the innate system that controls age-appropriate #behavior in a developing worm is not […]

Scientists find key proteins control risk of osteoarthritis during aging

Now, a study from scientists at The Scripps Research Institute (TSRI) explains why the risk of osteoarthritis increases as we #age and offers a potential avenue for developing new therapies to maintain healthy #joints. The study’s findings suggest that #FOXO proteins are responsible for the maintenance of healthy cells in the #cartilage of our joints. “We discovered that […]

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In Newly Created Life-Form, a Major Mystery | Quanta Magazine

Scientists have created a synthetic organism that possesses only the genes it needs to survive. But they have no idea what roughly a third of those genes do.

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Assay of nearly 5,000 mutations reveals roots of genetic splicing errors

Brown biologists have developed a new system, described in Nature Genetics, that identified and tracked hundreds of genetic variations that alter the way DNA is spliced when cells make proteins, often leading to disease.